Tetrahydrofuran → 2-Chloro-5-(4-isobutoxy-benzoyl)-benzenesulfonamide

HRID 144996Notes

Reaction equation

HRID 144996 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([O:8][CH2:9][CH:10]([CH3:11])[CH3:12])[cH:6][cH:7]1.[CH2:13]([Li:14])[CH2:15][CH2:16][CH3:17].[Cl:18][c:19]1[c:20]([S:31]([NH2:32])(=[O:33])=[O:34])[cH:21][c:22]([C:23](=[O:24])[N:25]([O:26][CH3:27])[CH3:28])[cH:29][cH:30]1.[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[c:2]1([C:23]([c:22]2[cH:21][c:20]([S:31]([NH2:32])(=[O:33])=[O:34])[c:19]([Cl:18])[cH:30][cH:29]2)=[O:24])[cH:3][cH:4][c:5]([O:8][CH2:9][CH:10]([CH3:11])[CH3:12])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 153241111-Bromo-4-(2-methylpropoxy)benzeneHCID 581073994-chloro-N-methoxy-N-methyl-3-sulfamoyl-benzamideHCID 178418339Butyllithium

Product 1

HCID 442357412-Chloro-5-(4-isobutoxy-benzoyl)-benzenesulfonamide

Sources & evidence

ORD record
ord-b45a9b28cfe846ec8288a9986d01c148
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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