Acetonitrile → Tert-butyl 4-((2-bromo-5-nitropyridin-4-ylamino)methyl)piperidine-1-carboxylate

HRID 144998Notes

Reaction equation

HRID 144998 reaction equation
[Br:16][c:17]1[n:18][cH:19][c:20]([N+:24](=[O:25])[O-:26])[c:21]([Cl:23])[cH:22]1.[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[CH3:34][C:35]#[N:36].[NH2:1][CH2:2][CH:3]1[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1>>[NH:1]([CH2:2][CH:3]1[CH2:4][CH2:5][N:6]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:7][CH2:8]1)[c:21]1[c:20]([N+:24](=[O:25])[O-:26])[cH:19][n:18][c:17]([Br:16])[cH:22]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 8471TriethylamineHCID 7368171-Boc-4-(aminomethyl)piperidineHCID 596134182-Bromo-4-chloro-5-nitropyridine

Product 1

HCID 59613428Tert-butyl 4-((2-bromo-5-nitropyridin-4-ylamino)methyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-f632946eabfd4ffa9fbd2c9162f280fa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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