HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Butanaminium, N,N,N-tributyl-, azide → 1-Benzyl-3-trifluoromethyl-3-(azidomethyl)pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Butanaminium, N,N,N-tributyl-, azide | HCID 5743232 | — |
| Reactant | 1-Benzyl-3-trifluoromethyl-3-(toluenesulfonyloxymethyl)pyrrolidine | HCID 86750299 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-Benzyl-3-trifluoromethyl-3-(azidomethyl)pyrrolidine | HCID 19691439 | — |
Reaction Steps
The compound (2.43 g) from step 456c was dissolved in acetonitrile, then reacted with tetrabutylammonium azide at 80° C. for 16 hours. The mixture was diluted with methylene chloride, then washed with water and brine and dried. Removal of the solvent gave 0.751 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05599816 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-3c4e7d40affa461d8caacef04405ca6a |
| Source note | uspto-grants-1997_02 |