(2R)-2-{[(tert-butoxy)carbonyl]amino}-3-cyclohexylpropanoic acid → HCID 178479446, compound

Participants

Reaction Steps

By methods substantially equivalent to those described in Example 1-A, 1-B, 1-C, 1-D, 1-H and 1-I, 2.14 g of NMI-D-Cha-Pro-Arg-H.HCl hydrate was prepared using Boc-D-Cha-OH in place of Boc-D-Phe-OH. Also, the tripeptide arginine lactam was reduced with LiAl(O-t-Bu)3H at -23° C. rather than LAH at -78° C.

Provenance & Evidence