反应详情

To a solution of polyphosphoric acid (200 mL) at 140° C. N-methoxycarbonyl-phenethylamine (28 g, 0.16 mol) was added portionwise over a 5 hour period. The reaction solution was poured into cold water (400 mL) and extracted with methylene chloride (5×200 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the title compound (17.96 g, 86% yield).

1. customat 140° C
2. extractionextracted with methylene chloride (5×200 mL)
3. dry with materialdried with anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationconcentrated