Sodium Iodide → HCID 86750329, compound

HRID 1450296Notes

Reaction equation

HRID 1450296 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]([C:14]2[N:15]3[CH:18]([CH:19]([CH3:33])[C:20]=2[S:21][CH:22]2[CH2:26][CH:25]([CH2:27]OS(C)(=O)=O)[O:24][CH2:23]2)[CH:17]([CH:34]([OH:36])[CH3:35])[C:16]3=[O:37])=[O:13])=[CH:6][CH:5]=1)([O-:3])=[O:2].[I-:38].[Na+]>CC(C)=O>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][O:11][C:12]([C:14]2[N:15]3[CH:18]([CH:19]([CH3:33])[C:20]=2[S:21][CH:22]2[CH2:26][CH:25]([CH2:27][I:38])[O:24][CH2:23]2)[CH:17]([CH:34]([OH:36])[CH3:35])[C:16]3=[O:37])=[O:13])=[CH:6][CH:5]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 5238Sodium IodideHCID 86750327HCID 86750327, compound

Product 1

HCID 86750329HCID 86750329, compoundYield 55.8%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 0.80 g of product from Example 57, 0.431 g of sodium iodide and 20 ml of acetone is heated at reflux temperature for 5 days. The reaction is concentrated in vacuo and the residue purified by chromatography (silica Gel: 80% ethyl acetate/hexane) to give 0.472 g of the desired product.

Workup

  1. temperatureis heated
  2. temperatureat reflux temperature for 5 days
  3. concentrationThe reaction is concentrated in vacuo
  4. customthe residue purified by chromatography (silica Gel: 80% ethyl acetate/hexane)

Sources & evidence

ORD record
ord-1eaadc2072ef4956af94b0b0934c4027
Source dataset
uspto-grants-1997_02
Patent number
US05602118

Reaction notes

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