Sodium methanolate methanol → HCID 131719850, compound

HRID 1450306Notes

Reaction equation

HRID 1450306 reaction equation
[CH3:1][N:2]1[CH:7]([S:8][CH2:9][C@@H:10]2[O:14][CH2:13][C@@H:12]([S:15]C(=O)C)[CH2:11]2)[NH:6][C:5](=[O:19])[C:4](=[O:20])[NH:3]1.C[O-].[Na+].CO>O1CCCC1>[CH3:1][N:2]1[CH:7]([S:8][CH2:9][C@H:10]2[CH2:11][C@H:12]([SH:15])[CH2:13][O:14]2)[NH:6][C:5](=[O:19])[C:4](=[O:20])[NH:3]1

Participants

4

Reactant 2

HCID 23694274Sodium methanolate methanolHCID 131719851HCID 131719851, compound

Product 1

HCID 131719850HCID 131719850, compoundYield 47.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound is prepared by the procedure of Example 16 using 0.357 g of product from Example 84, 281 microliter of 25% sodium methoxide/methyl alcohol and 500 microliter of tetrahydrofuran to give 0.148 g of the desired product.

Sources & evidence

ORD record
ord-49e421e0fbc44117be3e713d69a79c4d
Source dataset
uspto-grants-1997_02
Patent number
US05602118

Reaction notes

Loading…