反应详情

温度

100 °C

12.0 g (74.9 mmol) diethyl malonate were dissolved in 50 ml DMSO and 8.6 g (76.6 mmol) potassium t-butoxide were added. A solution of 7.9 g (50.1 mmol) 1-chloro-4-nitrobenzene in 50 ml DMSO was added via a dropping funnel. The mixture was heated at 100° C. for 4 h and poured on to crushed ice. It was extracted twice with ethyl acetate, the combined organic layers washed with brine, dried over sodium sulfate, and evaporated in vacuo to afford a brown oil, which contained the title compound in an amount of about 75% and which was used in the reaction of the next step.

1. additionpoured on
2. customto crushed ice
3. extractionIt was extracted twice with ethyl acetate
4. washthe combined organic layers washed with brine
5. dry with materialdried over sodium sulfate
6. customevaporated in vacuo
7. customto afford a brown oil, which