Hydrochloric Acid → HCID 67708649, compound

HRID 1450522Notes

Reaction equation

HRID 1450522 reaction equation
[C:1]([O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:15]=[N:16][N:17]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26][CH2:27][CH2:28][NH:29]C(OC(C)(C)C)=O)[N:18]=2)=[CH:10][CH:9]=1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[ClH:37]>>[ClH:37].[C:1]([O:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[N:15]=[N:16][N:17]([CH2:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[O:26][CH2:27][CH2:28][NH2:29])[N:18]=2)=[CH:10][CH:9]=1)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19977026HCID 19977026, compound

Product 1

HCID 67708649HCID 67708649, compoundYield 93%

Procedure

Hydrogen chloride (10 ml, 4N solution in ethyl acetate) was added to 4-[2-[2-[2-(t-butoxycarbonylamino)ethoxy]benzyl]tetrazol -5-yl]phenyl pivalate (200 mg), obtained in example 34, and the solution was allowed to stand in an ice box for 15 h. After the ethyl acetate was concentrated in vacuo, the resulting crystals were filtered and dried to give 160 mg (93%) of the title compound.

Workup

  1. customobtained in example 34
  2. concentrationAfter the ethyl acetate was concentrated in vacuo
  3. filtrationthe resulting crystals were filtered
  4. customdried

Sources & evidence

ORD record
ord-b33a8c00b8234857a77b3277ac694cef
Source dataset
uspto-grants-1997_02
Patent number
US05602161

Reaction notes

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