Dimethylformamide → HCID 178439896, compound

HRID 1450564Notes

Reaction equation

[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:12](C#N)[CH:11]=2)[C:7]2[CH:24]=[C:25]([N:31]3[CH2:39][C:38]4[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=4)[C:32]3=[O:40])[CH:26]=[C:27]([CH:28]([CH3:30])[CH3:29])[C:6]=2[N:5]=1)[CH2:2][CH3:3].[N-:41]=[N+:42]=[N-:43].[Na+].[CH3:45][N:46](C)C=O>>[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[C:45]3[NH:46][N:43]=[N:42][N:41]=3)=[CH:12][CH:11]=2)[C:7]2[CH:24]=[C:25]([N:31]3[CH2:39][C:38]4[C:33](=[CH:34][CH:35]=[CH:36][CH:37]=4)[C:32]3=[O:40])[CH:26]=[C:27]([CH:28]([CH3:29])[CH3:30])[C:6]=2[N:5]=1)[CH2:2][CH3:3]

Participants

Reactant 3

HCID 6228Dimethylformamide

HCID 33557Sodium Azide

HCID 57117891HCID 57117891, compound

Product 1

HCID 178439896HCID 178439896, compound

Procedure

Prepared analogously to Example 10 from 4-[[2-n-propyl-4-isopropyl-6-(1-oxo-isoindolin-2-yl)-benzimidazol-1-yl]-methyl]-2-cyano-biphenyl and sodium azide in dimethylformamide.

Sources & evidence

ORD record: ord-f9bede6ea7a84e6591fdb9460d886a7f
Source dataset: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05602127

Reaction notes

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