Stearoyl chloride → HCID 18920442, compound

HRID 1450632Notes

Reaction equation

HRID 1450632 reaction equation
[OH:1][CH:2]([CH2:15][OH:16])[C:3]#[C:4][C:5]1[S:9][C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[CH:7][CH:6]=1.[C:17](Cl)(=O)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]>ClCCl.N1C=CC=CC=1>[CH2:17]([O:1][CH:2]([CH2:15][O:16][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH3:17])[C:3]#[C:4][C:5]1[S:9][C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[CH:7][CH:6]=1)[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34]

Participants

5

Reactant 2

HCID 8212Stearoyl chlorideHCID 141868454-([2,2'-Bithiophen]-5-yl)but-3-yne-1,2-diol

Product 1

HCID 18920442HCID 18920442, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent2×

Procedure

170 mg (0.68 mmole) of 5-(3,4-dihydroxy-1-butynyl)-2,2-bithiophene was dissolved in a mixture of 10 ml of dichloromethane and 0.2 ml of pyridine. 0.7 g of stearoyl chloride dissolved in 10 ml of dichloromethane was then dropped into the reaction mixture in ice bath. This reaction solution was stirred for 2 days. It was monitored by thin layer chromatography to determine if there were 3 products obtained, i.e. a mixture of 1 diester and 2 monoesters.

Workup

  1. additionwas then dropped into the reaction mixture in ice bath
  2. customobtained

Sources & evidence

ORD record
ord-3ebba8eb355a4fbfbfd79ac9bd43a382
Source dataset
uspto-grants-1997_02
Patent number
US05602170

Reaction notes

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