HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-Phenyl-5-(2-(1-pyrrolidinylmethyl)butyryl)isoxazole hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Pyrrolidine, hydrochloride (1:1) | HCID 212848 | — |
| Reactant | 3-Phenyl-5-butyrylisoxazole | HCID 10130602 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Phenyl-5-(2-(1-pyrrolidinylmethyl)butyryl)isoxazole hydrochloride | HCID 132640 | — |
Reaction Steps
In a similar manner to Example 1, 14 g (85.1 mmol) of 3-phenyl-5-butyrylisoxazole, 8.4 g (78.5 mmol) of pyrrolidine hydrochloride, 2.6 g (86.7 mmol) of paraformaldehyde and 20 droplets of concentrated hydrochloric acid were reacted in 20 ml of dioxane so that 3-phenyl-5-{2-(1-pyrrolidinylmethyl)butyvyl} was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05602160 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-f6b1b0bf0f664a109bb45a3aa8da54c4 |
| Source note | uspto-grants-1997_02 |