Hydrochloric Acid → 3-Phenyl-5-(2-(1-pyrrolidinylmethyl)butyryl)isoxazole hydrochloride

HRID 1450649Notes

Reaction equation

HRID 1450649 reaction equation
[C:1]1([C:7]2[CH:11]=[C:10]([C:12](=[O:16])[CH2:13][CH2:14][CH3:15])[O:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:17].[NH:18]1[CH2:22][CH2:21][CH2:20][CH2:19]1.[CH2:23]=O.Cl>O1CCOCC1>[ClH:17].[C:1]1([C:7]2[CH:11]=[C:10]([C:12](=[O:16])[CH:13]([CH2:23][N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[CH2:14][CH3:15])[O:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 212848Pyrrolidine, hydrochloride (1:1)HCID 101306023-Phenyl-5-butyrylisoxazole

Product 1

HCID 1326403-Phenyl-5-(2-(1-pyrrolidinylmethyl)butyryl)isoxazole hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a similar manner to Example 1, 14 g (85.1 mmol) of 3-phenyl-5-butyrylisoxazole, 8.4 g (78.5 mmol) of pyrrolidine hydrochloride, 2.6 g (86.7 mmol) of paraformaldehyde and 20 droplets of concentrated hydrochloric acid were reacted in 20 ml of dioxane so that 3-phenyl-5-{2-(1-pyrrolidinylmethyl)butyvyl} was obtained.

Workup

  1. customwas obtained

Sources & evidence

ORD record
ord-f6b1b0bf0f664a109bb45a3aa8da54c4
Source dataset
uspto-grants-1997_02
Patent number
US05602160

Reaction notes

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