Thionyl Chloride → 3-(4-Methylphenyl)isoxazole-5-carboxylic acid chloride

Participants

Reaction Steps

Using 40 ml of thionyl chloride, 7.3 g (35.9 mmol) of 3-(4 -methylphenyl) isoxazole-5-carboxylic acid obtained above in the procedure (2) were refluxed for 4 hours in the presence of 0.1 ml of dimethylformamide. Thionyl chloride was distilled off under reduced pressure, followed by the addition of 100 ml of benzene. The resultant mixture was distilled under reduced pressure so that 3-(4-methylphenyl) isoxazole-5-carboxylic acid chloride was obtained as a solid. The solid was provided for the next step without purification.

Provenance & Evidence