反应详情

Using 40 ml of thionyl chloride, 7.3 g (35.9 mmol) of 3-(4 -methylphenyl) isoxazole-5-carboxylic acid obtained above in the procedure (2) were refluxed for 4 hours in the presence of 0.1 ml of dimethylformamide. Thionyl chloride was distilled off under reduced pressure, followed by the addition of 100 ml of benzene. The resultant mixture was distilled under reduced pressure so that 3-(4-methylphenyl) isoxazole-5-carboxylic acid chloride was obtained as a solid. The solid was provided for the next step without purification.

1. customobtained above in the procedure (2)
2. distillationThionyl chloride was distilled off under reduced pressure
3. additionfollowed by the addition of 100 ml of benzene
4. distillationThe resultant mixture was distilled under reduced pressure so that 3-(4-methylphenyl) isoxazole-5-carboxylic acid chloride
5. customwas obtained as a solid
6. customThe solid was provided for the next step without purification