Dichloromethane → 3-Piperidin-4-ylprop-2-ynyl methanesulfonate

HRID 145072Notes

Reaction equation

HRID 145072 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([C:14]#[C:15][CH2:16][O:17][S:18](=[O:19])(=[O:20])[CH3:21])[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:29][CH2:30][Cl:31].[F:22][C:23]([F:24])([F:25])[C:26]([OH:27])=[O:28]>>[NH:8]1[CH2:9][CH2:10][CH:11]([C:14]#[C:15][CH2:16][O:17][S:18](=[O:19])(=[O:20])[CH3:21])[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 865852774-(3-Methanesulfonyloxy-prop-1-ynyl)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 865852793-Piperidin-4-ylprop-2-ynyl methanesulfonate

Sources & evidence

ORD record
ord-a6214125812545448154acc058f5ce77
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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