1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → HCID 7577914, compound

HRID 1450723Notes

Reaction equation

HRID 1450723 reaction equation
[C:1]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=[O:11])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]>C(Cl)(Cl)Cl>[C:4]([O:11][C:10](=[O:12])[C@@H:9]1[CH2:13][CH2:14][CH2:15][N:8]1[C:1]([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2])([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 1

HCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

Product 1

HCID 7577914HCID 7577914, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

N-BOC-Proline tert-Butyl Ester (24) was synthesized from N-BOC-proline (14) according to the general procedure: yield, 90%; [α]25D -50.5° (c 3.4, CHCl3); 1H NMR δ 4.12 (dd, 1H, J=3.4, 8.9), 3.60-3.39 (m, 2H), 2.29-2.16 (m, 1H), 2.00-1.80 (m, 3H), 1.51 (s, 9H), 1.46 (s, 9H). Anal. Calcd for C14H26NO4 : C, 61.7; H, 9.6,; N, 5.1. Found: C, 61.7; H, 9.6; N, 5.4.

Workup

  1. customyield

Sources & evidence

ORD record
ord-1c83cde5b5c24df0b3d94a28ddbc3c27
Source dataset
uspto-grants-1997_02
Patent number
US05602264

Reaction notes

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