1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)- → HCID 7577914, compound

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Reaction Steps

N-BOC-Proline tert-Butyl Ester (24) was synthesized from N-BOC-proline (14) according to the general procedure: yield, 90%; [α]25D -50.5° (c 3.4, CHCl3); 1H NMR δ 4.12 (dd, 1H, J=3.4, 8.9), 3.60-3.39 (m, 2H), 2.29-2.16 (m, 1H), 2.00-1.80 (m, 3H), 1.51 (s, 9H), 1.46 (s, 9H). Anal. Calcd for C14H26NO4 : C, 61.7; H, 9.6,; N, 5.1. Found: C, 61.7; H, 9.6; N, 5.4.

Provenance & Evidence