4,6-Dichloro-5-nitropyrimidine → HCID 19358840, compound

HRID 1451046Notes

Reaction equation

HRID 1451046 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-])=O)=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[CH3:12][N:13]([CH3:18])[CH2:14][CH2:15][NH:16][CH3:17].[CH2:19]([C:21]1[NH:22][CH:23]=[C:24]([CH3:26])[N:25]=1)[CH3:20].[Sn](Cl)Cl.[C:30](N1C=CN=C1)(N1C=CN=C1)=[O:31]>>[CH2:19]([C:21]1[N:22]2[C:23]([C:30](=[O:31])[NH:8][C:7]3[C:2]([N:16]([CH3:17])[CH2:15][CH2:14][N:13]([CH3:18])[CH3:12])=[N:3][CH:4]=[N:5][C:6]=32)=[C:24]([CH3:26])[N:25]=1)[CH3:20]

Participants

6

Reactant 5

HCID 203124,6-Dichloro-5-nitropyrimidineHCID 24479Stannous ChlorideHCID 673381,2-Ethanediamine, N1,N1,N2-trimethyl-HCID 682631,1'-CarbonyldiimidazoleHCID 178437635HCID 178437635, compound

Product 1

HCID 19358840HCID 19358840, compound

Procedure

Prepared by treatment of 4,6-dichloro-5-nitropyrimidine with N,N,N'-trimethylethylenediamine followed by reaction with 2-ethyl-4-methylimidazole, reduction with tin (II) chloride and cyclization with carbonyldiimidazole.

Sources & evidence

ORD record
ord-4f7a51a616d64cfbb9b73411d88b6afa
Source dataset
uspto-grants-1997_02
Patent number
US05602252

Reaction notes

Loading…