反应详情

To a sample of methyl 3-(2-hydroxyethoxy)-4-nitrobenzoate (3.28 g, 0.0136 mol) dissolved in ethanol was added platinum oxide (50 mg). The mixture was hydrogenated for 40 min at 35 psi. Thin-layer chromatographic analysis (SiO2, 3:2 hexane:ethyl acetate) showed disappearance of starting material along with the formation of a new, lower-running spot (Rf =01) indicating the reaction was complete. The mixture was then filtered through a pad of Celite and the pad washed with fresh ethanol. The filtrate was concentrated and dried in vacuo to give 2.9 g (100%) of methyl 4-amino-3-(2-hydroxyethoxy)benzoate as an off-white solid.

1. filtrationThe mixture was then filtered through a pad of Celite
2. washthe pad washed with fresh ethanol
3. concentrationThe filtrate was concentrated
4. customdried in vacuo