Sodium Hydroxide → HCID 86750370, compound

HRID 1451095Notes

Reaction equation

HRID 1451095 reaction equation
[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11]C)=[O:10])=[CH:7][C:6]=1[CH:15]=[N:16][OH:17])(=[O:3])[CH3:2].[OH-].[Na+]>>[OH2:3].[C:1]([NH:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[CH:15]=[N:16][OH:17])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 85177110HCID 85177110, compound

Product 1

HCID 86750370HCID 86750370, compoundYield 131.8%

Procedure

A mixture of methyl 4-acetylamino-3-[(hydroxylimino)methyl]benzoate (142 mg, 0.6 mmol) and 1N sodium hydroxide (1.0 mL, 1.0 mmol) was stirred at room temperature for 4 h. The mixture was filtered through a pad of cotton and neutralized with dil. hydrochloric acid. The precipitate obtained was collected by filtration, washed with water, and dried under vacuum over acetone for 24 h to give 95 mg (71%) of the title compound as a white powder, mp 215°-218° C. (dec).

Workup

  1. filtrationThe mixture was filtered through a pad of cotton
  2. customThe precipitate obtained
  3. filtrationwas collected by filtration
  4. washwashed with water
  5. dry with materialdried under vacuum over acetone for 24 h

Sources & evidence

ORD record
ord-a0a84418c10d4d2aa3801e1b0499d2a2
Source dataset
uspto-grants-1997_02
Patent number
US05602277

Reaction notes

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