Hydrochloric Acid → HCID 67717390, compound

HRID 1451105Notes

Reaction equation

HRID 1451105 reaction equation
[NH2:1][CH2:2][CH:3]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:14]=1[NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:8]([O:10]C)=[O:9])[OH:4].[OH-].[Na+].Cl>>[OH2:4].[NH2:1][CH2:2][CH:3]([C:5]1[CH:6]=[C:7]([CH:12]=[CH:13][C:14]=1[NH:15][S:16]([CH3:19])(=[O:18])=[O:17])[C:8]([OH:10])=[O:9])[OH:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 10589423HCID 10589423, compound

Product 1

HCID 67717390HCID 67717390, compoundYield 152.9%

Procedure

A mixture of methyl 3-[2-amino-1-(R,S)-hydroxyethyl]-4-[(methylsulfonyl)amino]benzoate (50 mg, 0.17 mmol) in 1N sodium hydroxide (44 μL, 0.44 mmol) was stirred at room temperature for 4 h. The mixture was neutralized with dilute hydrochloric acid and let stand overnight at room temperature. A white precipitate accumulated which was collected by filtration, washed with water, and dried to give 38 mg (81%) of the title compound as a white powder, mp 274°-276° C.

Workup

  1. waitlet stand overnight at room temperature
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-d72a6b4484bd4709b22a03227f8cec77
Source dataset
uspto-grants-1997_02
Patent number
US05602277

Reaction notes

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