HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl Phosphate → Fludarabine Phosphate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl Phosphate | HCID 6535 | — |
| Reactant | Trimethyl Phosphate | HCID 10541 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Fludarabine | HCID 657237 | — |
| Solvent | Water | HCID 962 | — |
| Product | Fludarabine Phosphate | HCID 30751 | — |
Reaction Steps
Phosphorylation: The product from step (e) is mixed with phosphorous oxychloride in an alkyl phosphate such as triethylphosphate, or trimethylphosphate, followed by hydrolysis in water to yield the prodrug 9-β-D-arabinofuranosyl-2-fluoroadenine-5'-phosphate or fludarabine phosphate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05602246 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-3d182ccd67e644cba57efc186652ac7e |
| Source note | uspto-grants-1997_02 |