Thionyl Chloride → 5-Fluoro-2-nitrobenzoyl chloride

HRID 1451166Notes

Reaction equation

HRID 1451166 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:16])=O>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([Cl:16])=[O:8]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 27374205-Fluoro-2-nitrobenzoic acid

Product 1

HCID 156548685-Fluoro-2-nitrobenzoyl chloride

Procedure

A mixture of 5-fluoro-2-nitrobenzoic acid (47.51 g, 0.257 mol) and thionyl chloride (100 mL, 1.370 mol) is refluxed for several hours and concentrated in vacuo to give the title product which is used in Example 2 without further purification.

Workup

  1. temperatureis refluxed for several hours
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-3697ffb8d6ae47eaae98edc3f02bac4e
Source dataset
uspto-grants-1997_02
Patent number
US05604180

Reaction notes

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