HCID 11088367, compound → HCID 19974099, compound

HRID 1451359Notes

Reaction equation

[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].C[O:7][C:8]1[C:9]2[CH:10]=[C:11]3[S:20][CH:19]=[CH:18][N+:12]3=[CH:13][C:14]=2[CH:15]=[CH:16][CH:17]=1>Br>[Cl:1]([O-:5])(=[O:4])(=[O:3])=[O:2].[OH:7][C:8]1[C:9]2[CH:10]=[C:11]3[S:20][CH:19]=[CH:18][N+:12]3=[CH:13][C:14]=2[CH:15]=[CH:16][CH:17]=1

Participants

Conditions

Temperature: 115 °C

Procedure

A mixture of 9-methoxy-thiazolo[3,2-b]isoquinolinium perchlorate (7 g, 22.19 mmol) in 100 ml of 48% HBr was heated for 18 hours at 115° C. The mixture was concentrated in vacuo, the residue was dissolved in warm water and filtered. The filtrate was treated with sodium perchlorate, the resulting solid was filtered, and washed with water to afford 1.0 g (15%) of 9-hydroxy-thiazolo[3,2-b]isoquinolinium perchlorate (Formula II: A=thiazolo; R1 =H; R6 =9-OH; X- =ClO4-).

Workup

concentrationThe mixture was concentrated in vacuo
dissolutionthe residue was dissolved in warm water
filtrationfiltered
additionThe filtrate was treated with sodium perchlorate
filtrationthe resulting solid was filtered
washwashed with water

Sources & evidence

ORD record: ord-ef88c70a30c64e83b2f689109e61ec5f
Source dataset: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05604224

Reaction notes

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