Hydrogen Bromide → 2-Trifluoromethyl-5-methyl-4-bromoacetyl-thiazole
Reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[S:4][C:5]([CH3:11])=[C:6]([C:8](=[O:10])[CH3:9])[N:7]=1.[BrH:14].BrBr>C(O)(=O)C>[F:13][C:2]([F:1])([F:12])[C:3]1[S:4][C:5]([CH3:11])=[C:6]([C:8](=[O:10])[CH2:9][Br:14])[N:7]=1Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
3 g (0.0144 mol) of 2-Trifluoromethyl-5-methyl-4-acetyl-thiazole are dissolved in 30 ml of glacial acetic acid, and 2.1 ml of a 33% strength solution of hydrogen bromide in glacial acetic acid are added. The mixture is heated to 80° C. and, over the course of 30 minutes, a solution of 2.3 g (0.0144 mol) of bromine in 15 ml of glacial acetic acid is added. After a further 20 minutes, the glacial acetic acid is removed. The residue which remains is a dark oil which is reacted further as the crude product.
Workup
- customthe glacial acetic acid is removed
- customis reacted further as the crude product
Sources & evidence
- ORD record
- ord-b996ecb3d0ef40679d85387154f9e734
- Source dataset
- uspto-grants-1997_02
- Patent number
- US05604225
Reaction notes
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