Methyl 2-(4-(2-oxopropyl)phenoxy)acetate → N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(thiazol-4-yl)ethanamine

HRID 1451418Notes

Reaction equation

HRID 1451418 reaction equation
[OH:1][CH:2]([C:5]1[N:6]=[CH:7][S:8][CH:9]=1)[CH2:3][NH2:4].[C:10]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23](=O)[CH3:24])=[CH:18][CH:17]=1)([O:12][CH3:13])=[O:11]>>[C:10]([CH2:14][O:15][C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH:23]([NH:4][CH2:3][CH:2]([OH:1])[C:5]2[N:6]=[CH:7][S:8][CH:9]=2)[CH3:24])=[CH:20][CH:21]=1)([O:12][CH3:13])=[O:11]

Participants

3

Reactant 2

HCID 13851156Methyl 2-(4-(2-oxopropyl)phenoxy)acetateHCID 199741682-Amino-1-(thiazol-4-yl)ethanol

Product 1

HCID 19974207N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(thiazol-4-yl)ethanamine

Procedure

Prepared analogously to Example 13 by reaction of 2-hydroxy-2-(thiazol-4-yl)ethylamine with 1-(4-carbomethoxymethoxyphenyl)propan-2-one followed by purification of the base on a silica gel column using ethyl acetate/methanol=8:2 as eluant.

Workup

  1. customfollowed by purification of the base on a silica gel column

Sources & evidence

ORD record
ord-aa2ec2526c974f63bbe70a63311e1d5d
Source dataset
uspto-grants-1997_02
Patent number
US05604225

Reaction notes

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