Potassium Bicarbonate → HCID 14347783, compound

HRID 1451470Notes

Reaction equation

HRID 1451470 reaction equation
[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH:20]([C:22]3[N:23]=[C:24]([C:27]([F:30])([F:29])[F:28])[S:25][CH:26]=3)[O:19][C:18]([OH:40])([C:31]3N=C(C(F)(F)F)S[CH:35]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2].C(CO[C:47]1[CH:52]=CC(CC(NCC(O)C2N=C(C(F)(F)F)SC=2)C)=[CH:49][CH:48]=1)(OC)=O.FC(F)(F)C1SC=C(C(=O)CBr)N=1.C(=O)([O-])O.[K+]>CC(C)=O>[C:1]([CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH:14]([N:16]2[CH2:21][CH:20]([C:22]3[N:23]=[C:24]([C:27]([F:29])([F:28])[F:30])[S:25][CH:26]=3)[O:19][C:18]([OH:40])([C:31]3[CH:49]=[CH:48][CH:47]=[CH:52][CH:35]=3)[CH2:17]2)[CH3:15])=[CH:9][CH:8]=1)([O:3][CH3:4])=[O:2]

Participants

6

Reactant 4

HCID 516893Potassium BicarbonateHCID 10978660HCID 10978660, compoundHCID 14347763N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamineHCID 14347785HCID 14347785, compound

Product 1

HCID 14347783HCID 14347783, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

N-[2-(4-Carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2,6-bis(2-trifluoromethyl-thiazol-4-yl)morpholine from N-[2-(4-carbomethoxymethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(2-trifluoromethyl-thiazol-4-yl)ethanamine (pair of diastereomers A) with 2-trifluoromethyl-4-bromoacetyl-thiazole and potassium hydrogen carbonate in acetone.

Sources & evidence

ORD record
ord-fbcc31e750b74cf6992e80d619491b6f
Source dataset
uspto-grants-1997_02
Patent number
US05604225

Reaction notes

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