Sodium Hydroxide → HCID 23693686, compound

HRID 1451520Notes

Reaction equation

HRID 1451520 reaction equation
[Br:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([CH:18]([CH3:23])[CH2:19][C:20]([OH:22])=[O:21])=[C:8]2[CH3:24])=[CH:4][CH:3]=1.[OH-].[Na+:28]>CCO>[Br:1][C:2]1[CH:26]=[CH:25][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([O:16][CH3:17])=[CH:13][CH:14]=3)[C:9]([CH:18]([CH3:23])[CH2:19][C:20]([O-:22])=[O:21])=[C:8]2[CH3:24])=[CH:4][CH:3]=1.[Na+:28]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9803221HCID 9803221, compound

Product 1

HCID 23693686HCID 23693686, compoundYield 99.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of the acid from Step 5 (870 mg, 2.09 mmol) in 15 mL EtOH was treated with 1.00N NaOH (2.1 mL, 2.1 mmol), and stirred until the solid dissolved. The solution was concentrated to dryness, then dissolved in a minimum amount of water and freeze-dried to provide 914 mg of the title compound.

Workup

  1. dissolutiondissolved
  2. concentrationThe solution was concentrated to dryness
  3. dissolutiondissolved in a minimum amount of water
  4. customfreeze-dried

Sources & evidence

ORD record
ord-8e6ecd6f863a414da6031f1c4ed8d289
Source dataset
uspto-grants-1997_02
Patent number
US05604253

Reaction notes

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