Dichloromethane → 2-Ethyl-6-fluoro-1-phenyl-3-piperidin-4-YL-1H-indole

HRID 145155Notes

Reaction equation

HRID 145155 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][CH2:10][CH:11]([c:14]2[c:15]([CH2:30][CH3:31])[n:16](-[c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)[c:17]3[cH:18][c:19]([F:23])[cH:20][cH:21][c:22]23)[CH2:12][CH2:13]1)([CH3:5])([CH3:6])[CH3:7].[Cl:39][CH2:40][Cl:41].[OH:32][C:33]([C:34]([F:35])([F:36])[F:37])=[O:38]>>[NH:8]1[CH2:9][CH2:10][CH:11]([c:14]2[c:15]([CH2:30][CH3:31])[n:16](-[c:24]3[cH:25][cH:26][cH:27][cH:28][cH:29]3)[c:17]3[cH:18][c:19]([F:23])[cH:20][cH:21][c:22]23)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 587479994-(2-Ethyl-6-fluoro-1-phenyl-1H-indol-3-YL)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 587480002-Ethyl-6-fluoro-1-phenyl-3-piperidin-4-YL-1H-indole

Sources & evidence

ORD record
ord-bcc243aa3b754b00beb4775359f48967
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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