Sodium Hydroxide → HCID 86750378, compound

HRID 1451554Notes

Reaction equation

HRID 1451554 reaction equation
[CH3:1][C:2]1[C:6]([CH2:7][O:8][N:9]=[C:10]2[CH2:19][CH2:18][CH:17]([O:20][C:21](=[O:26])[CH:22]([CH3:25])[CH2:23][CH3:24])[CH:16]3[C:11]2=[CH:12][C:13](=[O:39])[CH:14]([CH3:38])[CH:15]3[CH2:27][CH2:28][C:29](=[O:37])[CH2:30][CH:31]([OH:36])[CH2:32][C:33]([OH:35])=[O:34])=[C:5]([CH3:40])[O:4][N:3]=1.[OH-].[Na+:42]>O1CCOCC1.O>[CH3:1][C:2]1[C:6]([CH2:7][O:8][N:9]=[C:10]2[CH2:19][CH2:18][CH:17]([O:20][C:21](=[O:26])[CH:22]([CH3:25])[CH2:23][CH3:24])[CH:16]3[C:11]2=[CH:12][C:13](=[O:39])[CH:14]([CH3:38])[CH:15]3[CH2:27][CH2:28][C:29](=[O:37])[CH2:30][CH:31]([OH:36])[CH2:32][C:33]([O-:35])=[O:34])=[C:5]([CH3:40])[O:4][N:3]=1.[Na+:42]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 86750379HCID 86750379, compound

Product 1

HCID 86750378HCID 86750378, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

139 mg of 7-[5-(3,5-dimethylisoxazol-4-yl)methoxyimino-2-methyl-8-(2-methylbutyryloxy)-3-oxo-1,2,3,5,6,7,8,8a-octahydro-1-naphthyl]-3-hydroxy-5-oxoheptanoic acid (prepared as described in Example 11b) were dissolved in 2.7 ml of a 1:1 by volume mixture of dioxane and water. 2.35 ml of a 0.1N aqueous solution of sodium hydroxide were added dropwise over a period of minutes at 0° C. to the solution, which was then stirred for 1 hour at room temperature. At the end of this time, the solution was freeze-dried, to obtain 140 mg of the title compound as a colorless moisture sensitive powder.

Workup

  1. customAt the end of this time, the solution was freeze-dried

Sources & evidence

ORD record
ord-f774057f74f749e69b99fbc3df7b5800
Source dataset
uspto-grants-1997_02
Patent number
US05604256

Reaction notes

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