Sodium Hydroxide → HCID 86750378, compound

Participants

Reaction Steps

139 mg of 7-[5-(3,5-dimethylisoxazol-4-yl)methoxyimino-2-methyl-8-(2-methylbutyryloxy)-3-oxo-1,2,3,5,6,7,8,8a-octahydro-1-naphthyl]-3-hydroxy-5-oxoheptanoic acid (prepared as described in Example 11b) were dissolved in 2.7 ml of a 1:1 by volume mixture of dioxane and water. 2.35 ml of a 0.1N aqueous solution of sodium hydroxide were added dropwise over a period of minutes at 0° C. to the solution, which was then stirred for 1 hour at room temperature. At the end of this time, the solution was freeze-dried, to obtain 140 mg of the title compound as a colorless moisture sensitive powder.

Provenance & Evidence