反应详情

温度

0 °C

In a reaction vessel equipped with a calcium chloride tube, 8.465 g of the compound of (2) above was dissolved in 85 ml of dichloromethane and 15.683 g of carbon tetrabromide and 14.867 g of triphenylphosphine were added thereto under ice-cooling. The mixture was stirred at 0° C. for 5 minutes. The reaction mixture was concentrated under reduced pressure and the residue was extracted with hexane. The hexane extract obtained was concentrated under reduced pressure and the residue was purified by silica gel column chromatography to give 7.964 g of 2-pentadecynyl bromide.

1. customIn a reaction vessel equipped with a calcium chloride tube
2. temperatureunder ice-cooling
3. concentrationThe reaction mixture was concentrated under reduced pressure
4. extractionthe residue was extracted with hexane
5. extractionThe hexane extract
6. customobtained
7. concentrationwas concentrated under reduced pressure
8. customthe residue was purified by silica gel column chromatography