Aluminium lithium hydride → 2-Amino-2-(1,2-dihydroxy-4-octadecenyl)-1,3-propanediol

HRID 1451612Notes

Reaction equation

HRID 1451612 reaction equation
[NH2:1][C:2]([CH:8]([OH:27])[CH:9]([OH:26])[CH2:10][CH:11]=[CH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])([CH2:6][OH:7])[C:3](O)=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:1][C:2]([CH:8]([OH:27])[CH:9]([OH:26])[CH2:10][CH:11]=[CH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])([CH2:3][OH:4])[CH2:6][OH:7]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 53930981HCID 53930981, compound

Product 1

HCID 538638012-Amino-2-(1,2-dihydroxy-4-octadecenyl)-1,3-propanediol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A lactone compound (978 mg) of 2-amino-3-hydroxy-2-(1,2-dihydroxy-4-octadecenyl)propionic acid and 403 mg of lithium aluminum hydride were reacted in 33 ml of dry tetrahydrofuran according to the method of Example 274 to give 222 mg of the subject compound.

Sources & evidence

ORD record
ord-1d8c6525e44f4fc79c0884efd2ebf9ab
Source dataset
uspto-grants-1997_02
Patent number
US05604229

Reaction notes

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