Aluminium lithium hydride → HCID 53764294, compound

HRID 1451613Notes

Reaction equation

HRID 1451613 reaction equation
[NH2:1][C:2]([CH:8]([OH:27])[CH2:9][CH2:10][CH:11]=[CH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[O:26])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])([CH2:6][OH:7])[C:3](O)=[O:4].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:1][C:2]([CH:8]([OH:27])[CH2:9][CH2:10][CH:11]=[CH:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH:19]([OH:26])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])([CH2:3][OH:4])[CH2:6][OH:7]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 53746549HCID 53746549, compound

Product 1

HCID 53764294HCID 53764294, compoundYield 26.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

According to the method of Example 274, 35.0 mg of 2-amino-3-hydroxy-2-(1-hydroxy-12-oxo-4-octadecenyl)propionic acid and 14.4 mg of lithium aluminum hydride were reacted in 2.0 ml of dry tetrahydrofuran to give 8.9 mg of the subject compound.

Sources & evidence

ORD record
ord-486cfa1912be413eaf028bee7fefba63
Source dataset
uspto-grants-1997_02
Patent number
US05604229

Reaction notes

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