反应详情

Using the general method of Example 91, 3-amino-4-(2-hydroxy-2-methylpropylamino)quinoline (46.2 g. 0.20 mol) was reacted with ethoxyacetic acid (62.5 g, 0.6 mol) to provide 53.6 g of crude product as a greyish solid. A small amount was recrystallized from toluene to provide 3.6 g of a colorless solid, m.p. 117°-120° C. Analysis: Calculated: % C 68.2; % H, 7.1; % N, 14.0; Found: % C, 68.5; % H, 7.1; % N, 14.0.

1. customto provide 53.6 g of crude product as a greyish solid
2. customA small amount was recrystallized from toluene