Propyl isocyanate → HCID 19972837, compound

HRID 1451774Notes

Reaction equation

HRID 1451774 reaction equation
[CH2:1]([N:4]=[C:5]=[O:6])[CH2:2][CH3:3].[NH2:7][CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH2:18][CH2:19][C:20](=[O:23])[NH:21][N:22]=3)[CH:14]=2)[CH2:9]1>COCCO>[CH2:1]([NH:4][C:5]([NH:7][CH:8]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:17]3[CH2:18][CH2:19][C:20](=[O:23])[NH:21][N:22]=3)[CH:14]=2)[CH2:9]1)=[O:6])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 61033Propyl isocyanateHCID 140714996-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

Product 1

HCID 19972837HCID 19972837, compoundYield 69.8%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Propyl isocyanate (2.38 g) was added dropwise to 5.13 g of 2-amino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane suspended in 60 ml of 2-methoxyethanol. The mixture was stirred at room temperature for 10 minutes. Crystals precipitated were collected by filtration and recrystallized from methanol-acetonitrile to obtain 4.91 g of 2-(propylcarbamoyl)amino-5-[4,5-dihydropyridazin-3(2H)-on-6-yl]indane.

Workup

  1. customCrystals precipitated
  2. filtrationwere collected by filtration
  3. customrecrystallized from methanol-acetonitrile

Sources & evidence

ORD record
ord-c8738fe4aa8b4ba1a4b00aad24f73a6e
Source dataset
uspto-grants-1997_02
Patent number
US05605901

Reaction notes

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