Triethylamine → HCID 54069381, compound

HRID 1451784Notes

Reaction equation

HRID 1451784 reaction equation
C(N(CC)CC)C.[NH2:8][CH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:19]3[CH:20]=[CH:21][C:22](=[O:25])[NH:23][N:24]=3)[CH:16]=2)[CH2:11]1.Br.[CH2:27]([N:30]=[C:31]=[O:32])[CH:28]=[CH2:29]>COCCO>[CH2:27]([NH:30][C:31]([NH:8][CH2:9][CH:10]1[CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:19]3[CH:20]=[CH:21][C:22](=[O:25])[NH:23][N:24]=3)[CH:16]=2)[CH2:11]1)=[O:32])[CH:28]=[CH2:29]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 15123Allyl isocyanateHCID 214762912-aminomethyl-5-[pyridazin-3(2H)-on-6-yl]indane hydrobromide

Product 1

HCID 54069381HCID 54069381, compoundYield 86.5%

Reagents, catalysts & solvents 1

HCID 80192-MethoxyethanolSolvent

Procedure

Triethylamine (1.05 g) was added to 40 ml of a suspension containing 2.70 g of 2-aminomethyl-5-[pyridazin-3(2H)-on-6-yl]indane·hydrobromide suspended in 2-methoxyethanol, and the mixture was stirred at room temperature for 10 minutes. To the mixture was added 1.10 g of allyl isocyanate, and the resulting mixture was stirred at room temperature for 1.5 hours. The reaction mixture was poured into ice water, and crystals precipitated were collected by filtration. The crystals obtained were washed with water, dried and then recrystallized from methanol to obtain 2.35 g of 2-[(ALLYLCARBAMOYL) amino]methyl-5-[pyridazin-3(2H)-on-6-yl]indane.

Workup

  1. stirringthe resulting mixture was stirred at room temperature for 1.5 hours
  2. customprecipitated
  3. filtrationwere collected by filtration
  4. customThe crystals obtained
  5. washwere washed with water
  6. customdried
  7. customrecrystallized from methanol

Sources & evidence

ORD record
ord-52d0bc0e0745418caaff364033ff91f2
Source dataset
uspto-grants-1997_02
Patent number
US05605901

Reaction notes

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