HCID 2779977, compound → HCID 10791746, compound

HRID 1451829Notes

Reaction equation

HRID 1451829 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[S:7]([CH:10]1[S:14][C:13](=[O:15])[NH:12][C:11]1=[O:16])(=[O:9])=[O:8].[F:17][C:18]([F:34])([F:33])[C:19]1[CH:20]=[C:21]([C:29]#[C:30][CH2:31]Br)[CH:22]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:24]=1.FC1C=C(C#CCBr)C=C(F)C=1>>[F:17][C:18]([F:33])([F:34])[C:19]1[CH:20]=[C:21]([C:29]#[C:30][CH2:31][C:10]2([S:7]([C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=3)(=[O:9])=[O:8])[S:14][C:13](=[O:15])[NH:12][C:11]2=[O:16])[CH:22]=[C:23]([C:25]([F:26])([F:27])[F:28])[CH:24]=1

Participants

4

Reactant 3

HCID 2779977HCID 2779977, compoundHCID 10491422HCID 10491422, compoundHCID 19973049HCID 19973049, compound

Product 1

HCID 10791746HCID 10791746, compound

Procedure

By the procedure described in Example 43, this compound was prepared from 5-(Pyridine-2-sulfonyl)-thiazolidine-2,4-dione of formula (V).Example 19 and [3-(3,5-bis(trifluoromethyl)phenyl)-prop-2-ynyl]-bromide of formula (IX), Example 31: mp 150°-152° C.: NMR (DMSO, d 6): δ8.79 (d, J=4.4 Hz, 1H, pyH), 8.16 (dr, J=1.6, 7.9 Hz, 1H, pyH), 8.11 (s, 1H, ArH), 8.05 (d, J=7.9 Hz, 1H, pyH), 7.94 (s, 2H, ArH), 7.9 (dd, J=4.9, 7.3 Hz, 1H, ArH), 3.87 (d, J=17.2 Hz, 1H, CH2), 3.71 (d, J=17.2 Hz, 1H, CH2); MS(CI): 509 (MI+1, 100%), 367 (32%), 366 (352%), 287 (35%), 194 (25%), 194 (20%); Anal. Calc. for C19H10F6N2O4S2 : C, 44.89; H, 1.98; N, 5.51; Found: C, 42.80; H, 2.09; N, 5.77.

Sources & evidence

ORD record
ord-a7bc340f91924479afc5edc2261f7fd1
Source dataset
uspto-grants-1997_02
Patent number
US05605918

Reaction notes

Loading…