1-Iodopropane → HCID 22923342, compound

HRID 1451887Notes

Reaction equation

HRID 1451887 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[N:6]([CH:13]1[CH2:18][CH2:17][N:16]([C:19]3[C:28]4[C:23](=[CH:24][C:25]([O:31][CH3:32])=[C:26]([O:29][CH3:30])[CH:27]=4)[N:22]=[CH:21][N:20]=3)[CH2:15][CH2:14]1)[C:5]2=[O:33].[CH2:34](I)[CH2:35][CH3:36]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]([CH2:34][CH2:35][CH3:36])[C:7](=[O:12])[N:6]([CH:13]1[CH2:14][CH2:15][N:16]([C:19]3[C:28]4[C:23](=[CH:24][C:25]([O:31][CH3:32])=[C:26]([O:29][CH3:30])[CH:27]=4)[N:22]=[CH:21][N:20]=3)[CH2:17][CH2:18]1)[C:5]2=[O:33]

Participants

3

Reactant 2

HCID 336431-IodopropaneHCID 229235436-Chloro-3-[1-(6,7-dimethoxy-4-quinazolinyl)-4-piperidinyl]-2,4(1H,3H)-quinazolinedione

Product 1

HCID 22923342HCID 22923342, compoundYield 63%

Procedure

The procedure similar to that described in Example 1 was repeated, except that 300 mg (0.64 mmol) of Compound h was used in place of Compound 24 and propyl iodide was used in place of methyl iodide. As a result, 200.9 mg (yield: 63%) of Compound 42 was obtained as white crystals.

Sources & evidence

ORD record
ord-7baa07d2919a485f8ad631e88b3a3629
Source dataset
uspto-grants-1997_02
Patent number
US05605900

Reaction notes

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