1-Iodopropane → HCID 22923414, compound

HRID 1451910Notes

Reaction equation

[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[N:8]=[CH:7][N:6]=[C:5]2[N:14]1[CH2:19][CH2:18][CH:17]([N:20]2[C:29](=[O:30])[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([CH3:31])[CH:27]=3)[N:22]([CH3:32])[C:21]2=[O:33])[CH2:16][CH2:15]1.[CH2:34](I)[CH2:35][CH3:36]>>[CH3:13][O:12][C:11]1[CH:10]=[C:9]2[C:4]([C:5]([N:14]3[CH2:19][CH2:18][CH:17]([N:20]4[C:29](=[O:30])[C:28]5[C:23](=[CH:24][CH:25]=[C:26]([CH3:31])[CH:27]=5)[N:22]([CH3:32])[C:21]4=[O:33])[CH2:16][CH2:15]3)=[N:6][CH:7]=[N:8]2)=[CH:3][C:2]=1[O:1][CH2:34][CH2:35][CH3:36]

Participants

Reactant 2

HCID 336431-Iodopropane

HCID 22923375HCID 22923375, compound

Product 1

HCID 22923414HCID 22923414, compoundYield 64%

Procedure

The procedure similar to that described in Example 1 was repeated, except that 100.0 mg (0.22 mmol) of Compound 90 obtained in Example 80 was used in place of Compound 24 and propyl iodide was used in place of methyl iodide. As a result, 69.0 mg (yield: 64%) of Compound 92 was obtained as white crystals.

Sources & evidence

ORD record: ord-06257e0355624365a4930fc7c4648ee2
Source dataset: uspto-grants-1997_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05605900

Reaction notes

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