反应详情

In 10 ml of methanol was dissolved 250.0 mg (0.47 mmol) of Compound 93 obtained in Example 84, and 5 ml of a 2N aqueous solution of sodium hydroxide was added thereto, followed by heating under reflux for 6 hours. After cooling, the reaction mixture was neutralized by addition of 4N hydrochloric acid, and extracted with chloroform. The organic layer was washed and dried, and the solvent was distilled off under reduced pressure. To the residue was added ether, and the precipitated crystals were collected by filtration and dried to give 77.8 mg (yield: 33%) of Compound 95 as white crystals.

1. additionwas added
2. temperatureby heating
3. temperatureunder reflux for 6 hours
4. temperatureAfter cooling
5. extractionextracted with chloroform
6. washThe organic layer was washed
7. customdried
8. distillationthe solvent was distilled off under reduced pressure
9. additionTo the residue was added ether
10. filtrationthe precipitated crystals were collected by filtration
11. customdried