反应详情

To a solution of dimethyl 4-cyano-4-(3-cyclopentyloxy-4-methoxyphenyl)pimelate (5.9 g, 14.6 mmol) in dry 1,2-dimethoxyethane (120 mL) under an argon atmosphere was added sodium hydride (80% suspension in mineral oil, 1.05 g, 43.8 mmol). The mixture was heated to reflux for 4.5 h, then was cooled to room temperature and was stirred for 16 h. Water was added and the reaction mixture was partitioned between ether and acidic water. The organic extract was dried (magnesium sulfate) and the solvent was removed in vacuo. The residue was purified by flash chromatography, eluting with 3:1 hexanes/ethyl acetate, to provide a white foam (4.9 g, 93%).

1. temperatureThe mixture was heated
2. temperatureto reflux for 4.5 h
3. customthe reaction mixture was partitioned between ether and acidic water
4. extractionThe organic extract
5. dry with materialwas dried (magnesium sulfate)
6. customthe solvent was removed in vacuo
7. customThe residue was purified by flash chromatography
8. washeluting with 3:1 hexanes/ethyl acetate