Hydrochloric Acid → HCID 19973197, compound

HRID 1451973Notes

Reaction equation

HRID 1451973 reaction equation
CC([N:5]([CH2:9][C:10](=[O:24])[NH:11][N:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]([C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)=[O:18])C(=O)[O-])(C)C.[ClH:25]>C(OCC)C>[ClH:25].[NH2:5][CH2:9][C:10]([NH:11][N:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]([C:19]1[S:20][CH:21]=[CH:22][CH:23]=1)=[O:18])=[O:24]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 867474411,1-dimethylethyl-[2-oxo-2-[[2-(2-thienylcarbonyl)-1H-pyrrol-1-yl]amino]ethyl]carbamate

Product 1

HCID 19973197HCID 19973197, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

To a solution of 1,1-dimethylethyl-[2-oxo-2-[[2-(2-thienylcarbonyl)-1H-pyrrol-1-yl]amino]ethyl]carbamate (6.20 g) in 200 ml of dry ethyl ether was added 80 ml of a 3.5M ethereal hydrogen chloride solution. The reaction mixture was stirred at room temperature for 7 days. The precipitate was collected by suction filtration, dissolved in 50 ml of hot isopropanol and evaporated in vacuo. The residual oil was crystallized from isopropanol/ethyl ether affording the product as crystals (2.61 g), m.p. 168°-169° C.

Workup

  1. filtrationThe precipitate was collected by suction filtration
  2. dissolutiondissolved in 50 ml of hot isopropanol
  3. customevaporated in vacuo
  4. customThe residual oil was crystallized from isopropanol/ethyl ether affording the product as crystals (2.61 g), m.p. 168°-169° C.

Sources & evidence

ORD record
ord-c1f01beb2732423d9d7988c4c2706a21
Source dataset
uspto-grants-1997_02
Patent number
US05605925

Reaction notes

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