反应详情

To a solution of 1,1-dimethylethyl-[2-oxo-2-[[2-(2-thienylcarbonyl)-1H-pyrrol-1-yl]amino]ethyl]carbamate (6.20 g) in 200 ml of dry ethyl ether was added 80 ml of a 3.5M ethereal hydrogen chloride solution. The reaction mixture was stirred at room temperature for 7 days. The precipitate was collected by suction filtration, dissolved in 50 ml of hot isopropanol and evaporated in vacuo. The residual oil was crystallized from isopropanol/ethyl ether affording the product as crystals (2.61 g), m.p. 168°-169° C.

1. filtrationThe precipitate was collected by suction filtration
2. dissolutiondissolved in 50 ml of hot isopropanol
3. customevaporated in vacuo
4. customThe residual oil was crystallized from isopropanol/ethyl ether affording the product as crystals (2.61 g), m.p. 168°-169° C.