HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 8-Hydroxy-5,6,7,8-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 5,6,7,8-Tetrahydroquinolin-8-yl acetate | HCID 12226249 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 8-Hydroxy-5,6,7,8-tetrahydroquinoline | HCID 11815939 | 102.5% |
Reaction Steps
To 10 g of 8-acetoxy-5,6,7,8-tetrahydroquinoline in 30 mL of methanol was added 30 mL of 30% sodium hydroxide in water. The mixture was heated to reflux for 2 min and the methanol was removed in vacuo. The residual organic product was extracted with chloroform. The chloroform extracts were dried over sodium sulfate and evaporation of the solvent gave 8 g of product as an oil, characterized by its NMR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05606054 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-23260d0c33794672ac69d32284680e56 |
| Source note | uspto-grants-1997_02 |