Thionyl Chloride → HCID 19973449, compound

HRID 1452043Notes

Reaction equation

HRID 1452043 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH2:10]O)=[CH:6][N:5]2[CH:12]=1.S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:15].[Cl:15][CH2:10][C:7]1[CH:8]=[CH:9][C:4]2[N:5]([CH:12]=[C:2]([CH3:1])[N:3]=2)[CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19973434HCID 19973434, compound

Product 1

HCID 19973449HCID 19973449, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

6.80 g of the 2-methylimidazo-[1,2-a]pyridine-6-methanol prepared in the Preparative Example 16 was dissolved in 90 ml of chloroform, followed by the dropwise addition of 6.1 ml of thionyl chloride under stirring at room temperature. After 2 hours, the solvent was distilled off. Crude 6-chloromethyl-2methylimidazo-[1,2-a]pyridine hydrochloride was obtained as a brown oil.

Workup

  1. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-d68fb8fe4ccd4e2a87e4aac04f1400b6
Source dataset
uspto-grants-1997_02
Patent number
US05606061

Reaction notes

Loading…