HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 1-bromo-3-ethyl-5-nitroBenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-Bromo-4-ethyl-6-nitroaniline | HCID 19973468 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-bromo-3-ethyl-5-nitroBenzene | HCID 18929870 | — |
Reaction Steps
Dissolve 4-ethyl-2-nitro-6-bromoaniline (6.62g, 27mmol) in ethanol (40mL). Add, by dropwise addition, concentrated sulfuric acid (5mL) and heat at reflux, adding sodium nitrite (4.55g, mmol) in small portions over 25 minutes. Stir at room temperature for several hours, pour onto ice and extract into ethyl acetate. Wash with water (3×) and brine (3×). Dry (MgSO4) and evaporate the solvent in vacuo and purify by silica gel chromatography to give 3-bromo-5-ethylnitrobenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05606063 |
| Source dataset | uspto-grants-1997_02 |
| ORD ID | ord-3537f4ef0a8b4604818f49ac23273f0b |
| Source note | uspto-grants-1997_02 |