Thionyl Chloride → HCID 19972426, compound

HRID 1452275Notes

Reaction equation

HRID 1452275 reaction equation
[C:1](/[CH:4]=[CH:5]/[C:6]1[C:15]2[O:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:12]([CH3:22])[C:11](=[O:23])[C:10]=2[CH:9]=[CH:8][CH:7]=1)(O)=[O:2].S(Cl)([Cl:26])=O>C1(C)C=CC=CC=1>[Cl:26][C:1](/[CH:4]=[CH:5]/[C:6]1[C:15]2[O:14][C:13]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[C:12]([CH3:22])[C:11](=[O:23])[C:10]=2[CH:9]=[CH:8][CH:7]=1)=[O:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19972449HCID 19972449, compound

Product 1

HCID 19972426HCID 19972426, compoundYield 69.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 9.2 g of Intermediate III and 7.8 g of thionyl chloride in 75 ml of toluene was refluxed for 3 hours. After cooling to 20°-25° C. the resultant crystal was collected by suction filtration, washed with acetone and dried in vacuo to give 6.8 g of the title compound, m.p. (190) 196°-198° C. after recrystallization from toluene.

Workup

  1. temperatureAfter cooling to 20°-25° C. the resultant crystal
  2. filtrationwas collected by suction filtration
  3. washwashed with acetone
  4. customdried in vacuo

Sources & evidence

ORD record
ord-910531e11a7041eaa0f5c88e8db6a1e4
Source dataset
uspto-grants-1997_02
Patent number
US05605896

Reaction notes

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