Trimethyl orthoformate → 4,4-Dimethoxytetrahydro-2H-pyran-3-ol

HRID 1452532Notes

Reaction equation

HRID 1452532 reaction equation
[OH:1][CH:2]1C(O)(S(O)(=O)=O)[CH2:6][CH2:5][O:4][CH2:3]1.[Na].CO[CH:16]([O:19][CH3:20])[O:17][CH3:18]>CO>[CH3:20][O:19][C:16]1([O:17][CH3:18])[CH2:6][CH2:5][O:4][CH2:3][CH:2]1[OH:1]

Participants

5

Reactant 3

HCID 9005Trimethyl orthoformateHCID 5360545SodiumHCID 723619783,4-dihydroxytetrahydro-2H-pyran-4-sulfonic acid

Product 1

HCID 121909884,4-Dimethoxytetrahydro-2H-pyran-3-ol

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

reacting said 3,4-dihydroxytetrahydro-2H-pyran-4-sulfonic acid, sodium salt with methanol and trimethylorthoformate in the presence of an acid to form 4,4-dimethoxytetrahydro-2H-pyran-3-ol; and

Sources & evidence

ORD record
ord-c785d8a6017b4713ae6b78ac4ac9b17a
Source dataset
uspto-grants-2009_01
Patent number
US07473696B2

Reaction notes

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