HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → (5R)-3-[3-Fluoro-4-(4-methyl-1,2,3-triazol-1-yl)phenyl]-5-(hydroxymethyl)oxazolidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Reactant | [3-Fluoro-4-(4-methyl-[1,2,3]triazol-1-yl)-phenyl]-carbamic acid benzyl ester | HCID 57526959 | — |
| Product | (5R)-3-[3-Fluoro-4-(4-methyl-1,2,3-triazol-1-yl)phenyl]-5-(hydroxymethyl)oxazolidin-2-one | HCID 57526994 | — |
Reaction Steps
[3-Fluoro-4-(4-methyl-[1,2,3]-triazol-1-yl)-phenyl]-carbamic acid benzyl ester (Intermediate 20) (56 g, 0.17 mol), lithium hexamethyldisilazide (LiHMDS) (1M/THF, 200 ml, 0.20 mol) and R-(−)-glycidyl butyrate (25 ml, 0.18 mol) were reacted following the procedure described for Intermediate 25. Chromatography on silica gel with 0-40% acetone in ethyl acetate, followed by trituration with acetone/ethyl acetate/chloroform/hexanes (300 ml/100 ml/100 ml/500 ml) overnight gave the title compound as an off-white solid (33.9 g), m.p. 190.2-192.0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07473699B2 |
| Source dataset | uspto-grants-2009_01 |
| ORD ID | ord-da97058d24a94fd2bb46d8032b7ad7ea |
| Source note | uspto-grants-2009_01 |